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The very hazardous and persistent aquatic pollutants known as polychlorinated biphenyls (PCBs) are known to bioaccumulate in a range of marine mammals. Human and animal studies have shown that exposure to PCBs affects the male reproductive system. This study was conducted to investigate the therapeutic effects of D-ribose-L-cysteine (DRLC) on PCB-mediated ATPase disruption of the neuroendocrine transmembrane ion pump and peroxynitrite formation in rat models. After the first 15 days of PCB treatment, DRLC (50 mg/kg) was administered orally for 15 days, beginning on day 16 and continuing through day 30. PCB (2 mg/kg) was administered for 30 days. All tests were performed in accordance with accepted procedures. Kisspeptin (kissp), gonadotropin-releasing hormone alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutathione peroxidase (GSH-Px), and total antioxidant capacity (TAOC) were all analyzed in blood on day 31. The testes were also removed and sent for testosterone, testicular antioxidant enzymes (LC and PrDx-4), androgenic enzymes (3β-HSD and 17β-HSD), sulfhydryl content, and transmembrane ion pump (Na+, K+, Ca 2+, Mg 2+, and H+ ions) The results of the study showed that Kisspeptin, GnRH, Testosterone, LC, PrDx-4, 3-HSD, 17-HSD, HOST, Na+, K+, Ca 2+, Mg 2+, and H+-ATPase levels were significantly increased by DRLC. In addition, DRLC therapy dramatically reduced levels of ONOO-, H2O2, 8-OHdG, ALP, and LDH, while increasing TAOC to restore GSH-Px levels. The results of the present study suggest that DRLC is a potentially effective therapeutic approach to reduce PCB …