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Crude oil has been reported to have adverse biological effects that are attributable to the dissolved low molecular weight hydrocarbons and metallic ions which are the major components of the water-soluble fraction of crude oil. Although, the protective effect of quercetin on testicular toxicity induced by the ingestion of Nigerian Bonny light crude oil has been reported. This study investigated the protective effects of quercetin on testicular toxicity induced by the water-soluble fraction of Nigerian Bonny light crude oil in male Wistar rats. Twenty (20) healthy male Wistar rats weighing about 100-120g were randomly selected into four major groups of five animals each. Animals were gavage daily with 1ml of distilled water (control), 1ml of 50% of water-soluble fraction of crude oil and quercetin at a dose of 10 mg/kg body weight for six (6) weeks. Serum testosterone level significantly decreased in male Wistar rats treated with water-soluble fraction of crude oil when compared to control (P<0.001). Moreover, water-soluble fraction of crude oil significantly increase testicular malondialdehyde (P<0.001), IL-1beta (p<0.01) and reduces superoxide dismutase (p<0.01), Zinc (p<0.001) and Potassium (p<0.01). Although, quercetin co-treated with water-soluble fraction ameliorates the adverse effect of water-soluble fraction on the levels of malondialdehyde, superoxide dismutase, Zinc and Potassium; it could not ameliorate the effects on serum testosterone and IL-1beta. The study suggests that water-soluble induces testicular toxicity through increase in lipid peroxidation and testicular IL-1β levels which could have resulted in low testosterone levels.