作者
Mahmut Ilker Yilmaz, Peter Stenvinkel, Alper Sonmez, Mutlu Saglam, Halil Yaman, Selim Kilic, Tayfun Eyileten, Kayser Caglar, Yusuf Oguz, Abdulgaffar Vural, Mustafa Çakar, Battal Altun, Mujdat Yenicesu, Juan Jesus Carrero
发表日期
2011/11/1
期刊
Nephrology dialysis transplantation
卷号
26
期号
11
页码范围
3537-3543
出版商
Oxford University Press
简介
Introduction. Systemic inflammation, endothelial dysfunction and arterial thickening contribute to the elevated cardiovascular risk of dialysis patients. However, the course of these derangements and their relative contribution to the cardiovascular risk of nondialysed chronic kidney disease (CKD) are scarcely investigated.
Methods. Flow-mediated dilatation (FMD) and intima-media thickness (IMT) were assessed in 304 nondialysed CKD patients Stages 1–5 (mean age 46 ± 12 years, 158 men), together with routine biochemical measurements, C-reactive protein (CRP) and insulin resistance. Patients were then followed for time-to-event analysis of cardiovascular outcomes (fatal and nonfatal).
Results. CRP and IMT increased, while FMD decreased in parallel with estimated glomerular filtration rate (eGFR) decline (P < 0.001 for all). CRP and intact parathormone, as well as eGFR …
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MI Yilmaz, P Stenvinkel, A Sonmez, M Saglam… - Nephrology dialysis transplantation, 2011
