作者
Zhenbo Han, Xiuxiu Wang, Zihang Xu, Yang Cao, Rui Gong, Yang Yu, Ying Yu, Xiaofei Guo, Shenzhen Liu, Meixi Yu, Wenya Ma, Yiming Zhao, Juan Xu, Xingda Li, Shuainan Li, Yan Xu, Ruijie Song, Binbin Xu, Fan Yang, Djibril Bamba, Natalia Sukhareva, Hong Lei, Manqi Gao, Wenwen Zhang, Naufal Zagidullin, Ying Zhang, Baofeng Yang, Zhenwei Pan, Benzhi Cai
发表日期
2021
期刊
Theranostics
卷号
11
期号
6
页码范围
3000
出版商
Ivyspring International Publisher
简介
N 6-methyladenosine (m 6 A) RNA modification, a dynamic and reversible process, is essential for tissue development and pathogenesis. However, the potential involvement of m 6 A in the regulation of cardiomyocyte (CM) proliferation and cardiac regeneration remains unclear. In this study, we aimed to investigate the essential role of m 6 A modification in heart regeneration during postnatal and adult injury.
Methods and results: In this study, we identified the downregulation of m 6 A demethylase ALKBH5, an m6A “eraser” that is responsible for increased m 6 A methylation, in the heart after birth. Notably, ALKBH5 knockout mice exhibited decreased cardiac regenerative ability and heart function after neonatal apex resection. Conversely, forced expression of ALKBH5 via adeno-associated virus-9 (AAV9) delivery markedly reduced the infarct size, restored cardiac function and promoted CM proliferation after …
学术搜索中的文章
Z Han, X Wang, Z Xu, Y Cao, R Gong, Y Yu, Y Yu… - Theranostics, 2021