作者
Matthew A Combs, Andrew J Golnar, Justin M Overcash, Alun L Lloyd, Keith R Hayes, David A O’Brochta, Kim M Pepin
发表日期
2023/8/1
来源
Trends in Genetics
卷号
39
期号
8
页码范围
609-623
出版商
Elsevier
简介
Engineered gene drives create potential for both widespread benefits and irreversible harms to ecosystems. CRISPR-based systems of allelic conversion have rapidly accelerated gene drive research across diverse taxa, putting field trials and their necessary risk assessments on the horizon. Dynamic process-based models provide flexible quantitative platforms to predict gene drive outcomes in the context of system-specific ecological and evolutionary features. Here, we synthesize gene drive dynamic modeling studies to highlight research trends, knowledge gaps, and emergent principles, organized around their genetic, demographic, spatial, environmental, and implementation features. We identify the phenomena that most significantly influence model predictions, discuss limitations of biological complexity and uncertainty, and provide insights to promote responsible development and model-assisted risk …
引用总数
学术搜索中的文章
MA Combs, AJ Golnar, JM Overcash, AL Lloyd… - Trends in Genetics, 2023