作者
Alexander C Razavi, SM Iftekhar Uddin, Zeina A Dardari, Daniel S Berman, Matthew J Budoff, Michael D Miedema, Albert D Osei, Olufunmilayo H Obisesan, Khurram Nasir, Alan Rozanski, John A Rumberger, Leslee J Shaw, Laurence S Sperling, Seamus P Whelton, Martin Bødtker Mortensen, Michael J Blaha, Omar Dzaye
发表日期
2022/7/1
期刊
Cardiovascular Imaging
卷号
15
期号
7
页码范围
1259-1270
出版商
American College of Cardiology Foundation
简介
Background
Coronary artery calcium (CAC) is a marker of plaque burden. Whether CAC improves risk stratification for incident sudden cardiac death (SCD) beyond atherosclerotic cardiovascular disease (ASCVD) risk factors is unknown.
Objectives
SCD is a common initial manifestation of coronary heart disease (CHD); however, SCD risk prediction remains elusive.
Methods
The authors studied 66,636 primary prevention patients from the CAC Consortium. Multivariable competing risks regression and C-statistics were used to assess the association between CAC and SCD, adjusting for demographics and traditional risk factors.
Results
The mean age was 54.4 years, 33% were women, 11% were of non-White ethnicity, and 55% had CAC >0. A total of 211 SCD events (0.3%) were observed during a median follow-up of 10.6 years, 91% occurring among those with baseline CAC >0. Compared with CAC = 0 …
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AC Razavi, SMI Uddin, ZA Dardari, DS Berman… - Cardiovascular Imaging, 2022