作者
Malek Zihlif, Nathir M Obeidat, Nadwa Zihlif, Tareq Mahafza, Tawfiq Froukh, Marcel T Ghanim, Hamza Beano, Fatima M Al-Akhras, Randa Naffa
发表日期
2016/3/1
期刊
Genetic testing and molecular biomarkers
卷号
20
期号
3
页码范围
143-148
出版商
Mary Ann Liebert, Inc.
简介
Introduction
Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood, and to a lesser extent with adult, asthma in many populations. Aims
In this study, we investigated the association between GSDMA and GSDMB variants and the incidence of adult and childhood asthma among Jordanians. Methods
Subjects were divided into two groups: adults and children. Within the adult group there were 129 asthma patients and 111 healthy controls. In the pediatric group there were 98 asthma patients and 112 healthy children. Gasdermin A (GSDMA) (rs7212938, T/G) and Gasdermin B (rs7216389, T/C) polymorphisms were genotyped using the PCR-RFLP method. Three analysis models were applied to the genotype data: co-dominant, dominant and recessive. Results
An association between the GSDMB T/C single nucleotide polymorphism (SNP) genotype and the incidence of childhood …学术搜索中的文章
M Zihlif, NM Obeidat, N Zihlif, T Mahafza, T Froukh… - Genetic testing and molecular biomarkers, 2016