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Method

PubMed database was searched on December 2021 with the following keywords:" acute lymphoblastic leukemia"," coagulation"," fibrinolysis" and" hemostatic." The inclusion criteria were: 1) study participants with childhood ALL, 2) hemostatic parameters were measured and reported at the time of diagnosis, 3) there is a comparator group of healthy subjects, and 4) there is no other reported comorbidities. Non-human studies, non-English articles and studies without healthy comparators were excluded. Data on coagulation profile at diagnosis were collected and meta-analyzed. The statistical method was random-effect inverse-variance weighting. The results were reported as mean difference with 95% confidence intervals (CIs)