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Plasma D-Dimer (DD) is a degradation product of cross-linked fibrin and represents the activation of the fibrinolytic and coagulation system. Clinically, DD tests have a high negative prediction value for thrombotic events and can be used to rule-out venous thromboembolism (VTE). The DD cut-off value for VTE in humans is 500 ng/mL; however, the baseline and cut-off values for rats are unknown.

To systematically evaluate the reported results and methodology of DD tests on rat models.

A systematic literature search was conducted using MEDLINE, EMBASE and Web of Science to include relevant full-length publications, published abstracts and conference proceedings from Jan-01-2000 to Dec-20-2019 that reported rat DD values. The search strategy used categorical search terms: “rat” AND “D-dimer” OR “fibrin degradation product”. Eligible articles were independently reviewed for strain …