作者
Natalia LS Machado, Stephen BG Abbott, Jon M Resch, Lin Zhu, Elda Arrigoni, Bradford B Lowell, Patrick M Fuller, Marco AP Fontes, Clifford B Saper
发表日期
2018/7/23
期刊
Current biology
卷号
28
期号
14
页码范围
2291-2301. e5
出版商
Elsevier
简介
Stress elicits a variety of autonomic responses, including hyperthermia (stress fever) in humans and animals. In this present study, we investigated the circuit basis for thermogenesis and heat conservation during this response. We first demonstrated the glutamatergic identity of the dorsal hypothalamic area (DHAVglut2) neurons that innervate the raphe pallidus nucleus (RPa) to regulate core temperature (Tc) and mediate stress-induced hyperthermia. Then, using chemogenetic and optogenetic methods to manipulate this hypothalamomedullary circuit, we found that activation of DHAVglut2 neurons potently drove an increase in Tc, but surprisingly, stress-induced hyperthermia was only reduced by about one-third when they were inhibited. Further investigation showed that DHAVglut2 neurons activate brown adipose tissue (BAT) but do not cause vasoconstriction, instead allowing reflex tail artery vasodilation as a …
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NLS Machado, SBG Abbott, JM Resch, L Zhu… - Current biology, 2018