作者
Jon M Resch, Joanne P Boisvert, Allison E Hourigan, Christopher R Mueller, Sun Shin Yi, SuJean Choi
发表日期
2011/12
期刊
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
卷号
301
期号
6
页码范围
R1625-R1634
出版商
American Physiological Society
简介
Numerous studies have demonstrated that the hypothalamic ventromedial nuclei (VMN) regulate energy homeostasis by integrating and utilizing behavioral and metabolic mechanisms. The VMN heavily express pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptors (PAC1R). Despite the receptor distribution, most PACAP experiments investigating affects on feeding have focused on intracerebroventricular administration or global knockout mice. To identify the specific contribution of PACAP signaling in the VMN, we injected PACAP directly into the VMN and measured feeding behavior and indices of energy expenditure. Following an acute injection of PACAP, nocturnal food intake was significantly reduced for 6 h after injections without evidence of malaise. In addition, PACAP-induced suppression of feeding also occurred following an overnight fast and could be blocked by a specific PAC1R …
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JM Resch, JP Boisvert, AE Hourigan, CR Mueller… - American Journal of Physiology-Regulatory, Integrative …, 2011