作者
Monica M Li, Joseph C Madara, Jennifer S Steger, Michael J Krashes, Nina Balthasar, John N Campbell, Jon M Resch, Nicholas J Conley, Alastair S Garfield, Bradford B Lowell
发表日期
2019/5/8
期刊
Neuron
卷号
102
期号
3
页码范围
653-667. e6
出版商
Elsevier
简介
SIM1-expressing paraventricular hypothalamus (PVH) neurons are key regulators of energy balance. Within the PVHSIM1 population, melanocortin-4 receptor-expressing (PVHMC4R) neurons are known to regulate satiety and bodyweight, yet they account for only half of PVHSIM1 neuron-mediated regulation. Here we report that PVH prodynorphin-expressing (PVHPDYN) neurons, which notably lack MC4Rs, function independently and additively with PVHMC4R neurons to account for the totality of PVHSIM1 neuron-mediated satiety. Moreover, PVHPDYN neurons are necessary for prevention of obesity in an independent but equipotent manner to PVHMC4R neurons. While PVHPDYN and PVHMC4R neurons both project to the parabrachial complex (PB), they synaptically engage distinct efferent nodes, the pre-locus coeruleus (pLC), and central lateral parabrachial nucleus (cLPBN), respectively. PB-projecting …
引用总数
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