作者
Victoria Lutgen, Jon Resch, Krista Qualmann, Nicholas J Raddatz, Cristina Panhans, Ellen M Olander, Linghai Kong, SuJean Choi, John R Mantsch, David A Baker
发表日期
2014/12
期刊
Psychopharmacology
卷号
231
页码范围
4637-4647
出版商
Springer Berlin Heidelberg
简介
Rationale
Gaps in our understanding of glutamatergic signaling may be key obstacles in accurately modeling complex CNS diseases. System xc - is an example of a poorly understood component of glutamate homeostasis that has the potential to contribute to CNS diseases.
Objectives
This study aims to determine whether system xc - contributes to behaviors used to model features of CNS disease states.
Methods
In situ hybridization was used to map mRNA expression of xCT throughout the brain. Microdialysis in the prefrontal cortex was used to sample extracellular glutamate levels; HPLC was used to measure extracellular glutamate and tissue glutathione concentrations. Acute administration of sulfasalazine (8–16 mg/kg, IP) was used to decrease system xc - activity …
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V Lutgen, J Resch, K Qualmann, NJ Raddatz… - Psychopharmacology, 2014