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The present study aims to evaluate the ameliorative effect of moringa extract and Vitamin E alone or their combination against Zinc Oxide (ZnO) Nanoparticles (NPs)-induced nephrotoxicity in rats. Eighty Male albino rats divided into eight groups. The 1st group (control) received distilled water. The 2rd group received Moring extract. The 3rd group was treated with Vitamin E. 4th group was administered ZnO Nps and group 5 received ZnO Nps in combination with Moringa extract. 6 received ZnO Nps in combination of Vitamin E. 7th group was administered ZnO Nps, moringa extract and Vitamin E. The 8th group was given ZnO Nps and Silymarin. After 45 days, blood and specimens were collected and renal function test parameters [urea, creatinine, uric acid and Blood Urea Nitrogen (BUN)] and lipid profile parameters were measured. The results showed that administration of ZnO Nps caused undesirable effects on studied biochemical parameters. The moringa and Vitamin E administration for 30 days subsequent to ZnO Nps exposure yielded significant ameliorative effects (decreased levels of renal function test parameters and lipid profile) on nearly all studied parameters and such effect found compatible with the effect caused by silymarin as a nephroprotective drug. The moringa extract in combination with Vitamin E had a significant ameliorative action on ZnO NPs induced oxidative damage and toxicity in rats. ZnO (NPs) increased urea, uric acid and creatinine, BUN, as well as decreased the lipid profile parameters. Hepatic and renal protection was maximum in the combined treatment of …