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Objective:

To study the safety and the effects of early continuous hypertonic saline infusion in patients with cerebral edema and underlying cerebrovascular disease.

Design:

Retrospective analysis.

Setting:

University medical center.

Patients:

Neurologic intensive care unit population with mixed cerebrovascular diseases.

Interventions:

None.

Measurements and Main Results:

Between May 2008 and December 2009, 100 patients with severe intracerebral hemorrhage, cerebral ischemia, or aneurysmal subarachnoid hemorrhage and signs of intracranial hypertension received within≤ 72 hrs after symptom onset a continuous infusion of hypertonic saline (3%, target sodium 145–155 mmol/L, target osmolality 310–320 mOsm/kg) over 13 (4–23) days. We analyzed the frequency of episodes with elevated intracranial pressure (new anisocoria or intracranial pressure> 20 mm Hg for≥ 20 mins), inhospital mortality, and the …