作者
Karin Keppeler, Aline Pesi, Simon Lange, Johanna Helmstädter, Lea Strohm, Henning Ubbens, Marin Kuntić, Ivana Kuntić, Dominika Mihaliková, Ksenija Vujačić-Mirski, Alexandra Rosenberger, Leonie Küster, Charlotte Frank, Matthias Oelze, Stefanie Finger, Agnieszka Zakrzewska, Elena Verdu, Johannes Wild, Susanne Karbach, Philip Wenzel, Philipp Wild, David Leistner, Thomas Münzel, Andreas Daiber, Detlef Schuppan, Sebastian Steven
发表日期
2024/4/1
期刊
Redox Biology
卷号
70
页码范围
103071
出版商
Elsevier
简介
Aims
We examined the cardiovascular effects of celiac disease (CeD) in a humanized mouse model, with a focus on vascular inflammation, endothelial dysfunction, and oxidative stress.
Methods and results
NOD.DQ8 mice genetically predisposed to CeD were subjected to a diet regime and oral gavage to induce the disease (gluten group vs. control). We tested vascular function, confirmed disease indicators, and evaluated inflammation and oxidative stress in various tissues. Plasma proteome profiling was also performed.
CeD markers were confirmed in the gluten group, indicating increased blood pressure and impaired vascular relaxation. Pro-inflammatory genes were upregulated in this group, with increased CD11b+ myeloid cell infiltration and oxidative stress parameters observed in aortic and heart tissue. However, heart function remained unaffected. Plasma proteomics suggested the cytokine interleukin-17A …
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K Keppeler, A Pesi, S Lange, J Helmstädter, L Strohm… - Redox Biology, 2024