作者
Alica Hartmann, Stephanie Desirée Grabitz, Felix Mathias Wagner, Philipp Sebastian Wild, Martina Müller-Nurasyid, Karl Johannes Lackner, Manfred Elmar Beutel, Thomas Münzel, Oliver Tüscher, Jörn Markus Schattenberg, Norbert Pfeiffer, Alexander Karl-Georg Schuster
发表日期
2024/6
期刊
Graefe's Archive for Clinical and Experimental Ophthalmology
卷号
262
期号
6
页码范围
1819-1828
出版商
Springer Berlin Heidelberg
简介
Purpose
The aim of this study is to investigate the distribution of spherical equivalent and axial length in the general population and to analyze the influence of education on spherical equivalent with a focus on ocular biometric parameters.
Methods
The Gutenberg Health Study is a population-based cohort study in Mainz, Germany. Participants underwent comprehensive ophthalmologic examinations as part of the 5-year follow-up examination in 2012–2017 including genotyping. The spherical equivalent and axial length distributions were modeled with gaussian mixture models. Regression analysis (on person-individual level) was performed to analyze associations between biometric parameters and educational factors. Mendelian randomization analysis explored the causal effect between spherical equivalent, axial length, and education. Additionally, effect mediation analysis examined the link between spherical …
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A Hartmann, SD Grabitz, FM Wagner, PS Wild… - Graefe's Archive for Clinical and Experimental …, 2024