作者
Johannes T Neumann, Raphael Twerenbold, Francisco Ojeda, Nils A Sörensen, Andrew R Chapman, Anoop SV Shah, Atul Anand, Jasper Boeddinghaus, Thomas Nestelberger, Patrick Badertscher, Arash Mokhtari, John W Pickering, Richard W Troughton, Jaimi Greenslade, William Parsonage, Matthias Mueller-Hennessen, Tommaso Gori, Tomas Jernberg, Niall Morris, Christoph Liebetrau, Christian Hamm, Hugo A Katus, Thomas Münzel, Ulf Landmesser, Veikko Salomaa, Licia Iacoviello, Marco M Ferrario, Simona Giampaoli, Frank Kee, Barbara Thorand, Annette Peters, Rossana Borchini, Torben Jørgensen, Stefan Söderberg, Susana Sans, Hugh Tunstall-Pedoe, Kari Kuulasmaa, Thomas Renné, Karl J Lackner, Andrew Worster, Richard Body, Ulf Ekelund, Peter A Kavsak, Till Keller, Bertil Lindahl, Philipp Wild, Evangelos Giannitsis, Martin Than, Louise A Cullen, Nicholas L Mills, Christian Mueller, Tanja Zeller, Dirk Westermann, Stefan Blankenberg
发表日期
2019/6/27
期刊
New England Journal of Medicine
卷号
380
期号
26
页码范围
2529-2540
出版商
Massachusetts Medical Society
简介
Background
Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful in determining the probability of myocardial infarction and subsequent 30-day outcomes.
Methods
In 15 international cohorts of patients presenting to the emergency department with symptoms suggestive of myocardial infarction, we determined the concentrations of high-sensitivity troponin I or high-sensitivity troponin T at presentation and after early or late serial sampling. The diagnostic and prognostic performance of multiple high-sensitivity troponin cutoff combinations was assessed with the use of a derivation–validation design. A risk-assessment tool that was based on these data was developed to estimate the risk of index myocardial infarction and of subsequent myocardial infarction or death at 30 days.
Results
Among 22 …
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JT Neumann, R Twerenbold, F Ojeda, NA Sörensen… - New England Journal of Medicine, 2019