作者
Masaki Fujita, John M Shannon, Charles G Irvin, Karen A Fagan, Carlyne Cool, Andrei Augustin, Robert J Mason
发表日期
2001/1/1
期刊
American Journal of Physiology-Lung Cellular and Molecular Physiology
卷号
280
期号
1
页码范围
L39-L49
出版商
American Physiological Society
简介
Tumor necrosis factor (TNF)-α is a key proinflammatory cytokine that is thought to be important in the development of pulmonary fibrosis, whereas its role in pulmonary emphysema has not been as thoroughly documented. In the present study, TNF-α was overexpressed in alveolar type II cells under the control of the human surfactant protein C promoter. In this report, we further characterized the pulmonary abnormalities and provided a physiological assessment of these mice. Histopathology of the lungs revealed chronic inflammation, severe alveolar air space enlargement and septal destruction, and bronchiolitis. However, pulmonary fibrosis was very limited and only seen in the subpleural, peribronchiolar, and perivascular regions. Physiological assessment showed an increase in lung volumes and a decrease in elastic recoil characteristic of emphysema; there was no evidence of restrictive lung disease …
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M Fujita, JM Shannon, CG Irvin, KA Fagan, C Cool… - American Journal of Physiology-Lung Cellular and …, 2001