作者
Vatche G Agopian, Maud M Morshedi, Justin McWilliams, Michael P Harlander-Locke, Daniela Markovic, Ali Zarrinpar, Fady M Kaldas, Douglas G Farmer, Hasan Yersiz, Jonathan R Hiatt, Ronald W Busuttil
发表日期
2015/9/1
期刊
Annals of surgery
卷号
262
期号
3
页码范围
536-545
出版商
LWW
简介
Objectives:
To evaluate the rate, effect, and predictive factors of a complete pathologic response (cPR) in patients with hepatocellular carcinoma (HCC) undergoing locoregional therapy (LRT) before liver transplantation (LT).
Background:
Eligible patients with HCC receive equal model for end-stage liver disease prioritization, despite variable risks of tumor progression, waitlist dropout, and posttransplant recurrence. Pretransplant LRT mitigates these risks by inducing tumor necrosis.
Methods:
Comparisons were made among HCC recipients with cPR (n= 126) and without cPR (n= 375) receiving pre-LT LRT (1994–2013). Multivariable predictors of cPR were identified.
Results:
Of 501 patients, 272, 148, and 81 received 1, 2, and 3 or more LRT treatments. The overall, recurrence-free, and disease-specific survival at 1-, 3-, and 5 years was 86%, 71%, 63%; 84%, 67%, 60%; and 97%, 90%, 87%. Compared with recipients …
学术搜索中的文章
VG Agopian, MM Morshedi, J McWilliams… - Annals of surgery, 2015