作者
Helen Kim, Jeffrey Nelson, Timo Krings, Karel G Terbrugge, Charles E McCulloch, Michael T Lawton, William L Young, Marie E Faughnan, BVMC HHT Investigator Group, Murali Chakinala, James R Gossage, Katharine Henderson, Vivek Iyer, Raj Kasthuri, Doris Lin, Johannes Jurgen Mager, Justin McWilliams, Jamie McDonald, Ludmila Pawlikowska, Jeffrey Pollak, Felix Ratjen, Karen Swanson, Dilini Vethanayagam, Andrew White, Robert I White Jr, Pearce Wilcox
发表日期
2015/5
期刊
Stroke
卷号
46
期号
5
页码范围
1362-1364
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Hereditary hemorrhagic telangiectasia (HHT) is a systemic disease characterized by mucocutaneous telangiectasias, epistaxis, and arteriovenous malformations (AVMs). Intracranial hemorrhage (ICH) rates in this population are not well described. We report ICH rates and characteristics in HHT patients with brain AVMs (HHT-BAVMs).
Methods
We studied the first 153 HHT-BAVM patients with follow-up data enrolled in the Brain Vascular Malformation Consortium HHT Project. We estimated ICH rates after BAVM diagnosis.
Results
The majority of patients were women (58%) and white (98%). The mean age at BAVM diagnosis was 31±19 years (range, 0–70), with 61% of cases diagnosed on asymptomatic screening. Overall, 14% presented with ICH; among symptomatic cases, 37% presented ruptured. During 493 patient-years of follow-up, 5 ICH events occurred yielding a rate of 1.02% per …
学术搜索中的文章
H Kim, J Nelson, T Krings, KG Terbrugge… - Stroke, 2015