作者
Carsten G Hansen, Nicholas A Bright, Gillian Howard, Benjamin J Nichols
发表日期
2009/7
期刊
Nature cell biology
卷号
11
期号
7
页码范围
807-814
出版商
Nature Publishing Group UK
简介
Caveolae are plasma membrane invaginations with a characteristic flask-shaped morphology. They function in diverse cellular processes, including endocytosis. The mechanism by which caveolae are generated is not fully understood, but both caveolin proteins and PTRF (polymerase I and transcript release factor, also known as cavin) are important. Here we show that loss of SDPR (serum deprivation protein response) causes loss of caveolae. SDPR binds directly to PTRF and recruits PTRF to caveolar membranes. Overexpression of SDPR, unlike PTRF, induces deformation of caveolae and extensive tubulation of the plasma membrane. The B-subunit of Shiga toxin (STB) also induces membrane tubulation and these membrane tubes also originate from caveolae. STB colocalizes extensively with both SDPR and caveolin 1. Loss of caveolae reduces the propensity of STB to induce membrane tubulation. We …
引用总数
学术搜索中的文章
CG Hansen, NA Bright, G Howard, BJ Nichols - Nature cell biology, 2009