作者
Sara M Willems, Daniel J Wright, Felix R Day, Katerina Trajanoska, Peter K Joshi, John A Morris, Amy M Matteini, Fleur C Garton, Niels Grarup, Nikolay Oskolkov, Anbupalam Thalamuthu, Massimo Mangino, Jun Liu, Ayse Demirkan, Monkol Lek, Liwen Xu, Guan Wang, Christopher Oldmeadow, Kyle J Gaulton, Luca A Lotta, Eri Miyamoto-Mikami, Manuel A Rivas, Tom White, Po-Ru Loh, Mette Aadahl, Najaf Amin, John R Attia, Krista Austin, Beben Benyamin, Søren Brage, Yu-Ching Cheng, Paweł Cięszczyk, Wim Derave, Karl-Fredrik Eriksson, Nir Eynon, Allan Linneberg, Alejandro Lucia, Myosotis Massidda, Braxton D Mitchell, Motohiko Miyachi, Haruka Murakami, Sandosh Padmanabhan, Ashutosh Pandey, Ioannis Papadimitriou, Deepak K Rajpal, Craig Sale, Theresia M Schnurr, Francesco Sessa, Nick Shrine, Martin D Tobin, Ian Varley, Louise V Wain, Naomi R Wray, Cecilia M Lindgren, Daniel G MacArthur, Dawn M Waterworth, Mark I McCarthy, Oluf Pedersen, Kay-Tee Khaw, Douglas P Kiel, Yannis Pitsiladis, Noriyuki Fuku, Paul W Franks, Kathryn N North, Cornelia M van Duijn, Karen A Mather, Torben Hansen, Ola Hansson, Tim Spector, Joanne M Murabito, J Brent Richards, Fernando Rivadeneira, Claudia Langenberg, John RB Perry, Nick J Wareham, Robert A Scott
发表日期
2017/7/12
期刊
Nature communications
卷号
8
期号
1
页码范围
16015
出版商
Nature Publishing Group UK
简介
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10−8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength …
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SM Willems, DJ Wright, FR Day, K Trajanoska… - Nature communications, 2017