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This cross-sectional, population-based study explores the effects of age and gender on resilience and protective factors for mental health in primary school aged children in Brisbane, Australia. Surveys were administered to 1109 male and 1163 female students (N = 2492) in 2004 to assess self-perception of resilience and associated protective factors. Female students are found to be more likely to report higher levels of communication, empathy, help-seeking and goals for future and aspirations. They also report more positive connections with parents, teachers and adults in the community, and peers in school and outside school, as well as sense of autonomy experience. These differences, however, show changes over time. The interaction between age and gender is significant for empathy and help-seeking, and for adult support at home, at school and in the community, peer support at school and outside schools …