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Highlights•Secondary prevention interventions in LMICs are economically beneficial.•Two attractive interventions can provide one-half of the reduced NCD mortality target for 2030.We present a quantitative economic benefit-cost analysis of 2 secondary prevention targets that are part of the World Health Organization's Global Monitoring Framework for noncommunicable diseases (NCD). These targets are expected to contribute to the achievement of the overall NCD target proposed for the Post-2015 Sustainable Development Goal Framework. We estimate that interventions would need to avert roughly 6 million to 7 million NCD deaths worldwide in 2030 to meet the target. We calculate that the combination of tobacco taxation that achieves 50% reduction in use and 70% coverage of high-risk populations with a multidrug regimen can provide one-half of that mortality reduction in 2030, at a benefit-cost ratio of 7: 1, or …