作者
Rima S Zahr, Marianne E Yee, Jack Weaver, Katherine Twombley, Raed Bou Matar, Diego Aviles, Rajasree Sreedharan, Michelle N Rheault, Rossana Malatesta-Muncher, Hillarey Stone, Tarak Srivastava, Gaurav Kapur, Poornima Baddi, Oded Volovelsky, Jonathan Pelletier, Rasheed Gbadegesin, Wacharee Seeherunvong, Hiren P Patel, Larry A Greenbaum
发表日期
2019/8/1
期刊
Pediatric nephrology
卷号
34
页码范围
1435-1445
出版商
Springer Berlin Heidelberg
简介
Background
Renal damage is a progressive complication of sickle cell disease (SCD). Microalbuminuria is common in children with SCD, while a smaller number of children have more severe renal manifestations necessitating kidney biopsy. There is limited information on renal biopsy findings in children with SCD and subsequent management and outcome.
Methods
This is a multicenter retrospective analysis of renal biopsy findings and clinical outcomes in children and adolescents with SCD. We included children and adolescents (age ≤ 20 years) with SCD who had a kidney biopsy performed at a pediatric nephrology unit. The clinical indication for biopsy, biopsy findings, subsequent treatments, and outcomes were analyzed.
Results
Thirty-six SCD patients (ages 4–19 years) were identified from 14 centers with a …
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RS Zahr, ME Yee, J Weaver, K Twombley, RB Matar… - Pediatric nephrology, 2019