作者
Roddy Hiram, Feng Xiong, Patrice Naud, Jiening Xiao, Deanna K Sosnowski, Ewen Le Quilliec, Arnela Saljic, Issam H Abu-Taha, Markus Kamler, Charles-Alexandre LeBlanc, Doa’a GF Al-U’Datt, Martin G Sirois, Terence E Hebert, Jean-François Tanguay, Jean-Claude Tardif, Dobromir Dobrev, Stanley Nattel
发表日期
2024/3
期刊
Cardiovascular Research
卷号
120
期号
4
页码范围
345-359
出版商
Oxford University Press
简介
Aims
Recent studies suggest that bioactive mediators called resolvins promote an active resolution of inflammation. Inflammatory signalling is involved in the development of the substrate for atrial fibrillation (AF). The aim of this study is to evaluate the effects of resolvin-D1 on atrial arrhythmogenic remodelling resulting from left ventricular (LV) dysfunction induced by myocardial infarction (MI) in rats.
Methods and results
MI was produced by left anterior descending coronary artery ligation. Intervention groups received daily intraperitoneal resolvin-D1, beginning before MI surgery (early-RvD1) or Day 7 post-MI (late-RvD1) and continued until Day 21 post-MI. AF vulnerability was evaluated by performing an electrophysiological study. Atrial conduction was analysed by using optical mapping. Fibrosis was quantified by Masson’s trichrome staining and gene expression by …
学术搜索中的文章
R Hiram, F Xiong, P Naud, J Xiao, DK Sosnowski… - Cardiovascular Research, 2024