作者
Roddy Hiram, Patrice Naud, Feng Xiong, Doa’a Al-u’datt, Vincent Algalarrondo, Martin G Sirois, Jean-François Tanguay, Jean-Claude Tardif, Stanley Nattel
发表日期
2019/9/10
期刊
Journal of the American College of Cardiology
卷号
74
期号
10
页码范围
1332-1347
出版商
American College of Cardiology Foundation
简介
Background
Conditions affecting the right heart, including diseases of the lungs and pulmonary circulation, promote atrial fibrillation (AF), but the mechanisms are poorly understood.
Objectives
This study sought to determine whether right heart disease promotes atrial arrhythmogenesis in a rat model of pulmonary hypertension (PH) and, if so, to define the underlying mechanisms.
Methods
PH was induced in male Wistar rats with a single intraperitoneal injection of 60 mg/kg of monocrotaline, and rats were studied 21 days later when right heart disease was well developed. AF vulnerability was assessed in vivo and in situ, and mechanisms were defined by optical mapping, histochemistry, and biochemistry.
Results
Monocrotaline-treated rats developed increased right ventricular pressure and mass, along with right atrial (RA) enlargement. AF/flutter was inducible in 32 of 32 PH rats (100%) in vivo and 11 of 12 (92%) in …
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R Hiram, P Naud, F Xiong, D Al-u'datt, V Algalarrondo… - Journal of the American College of Cardiology, 2019