作者
Anne WS Rutjes, Peter Jüni, Bruno R da Costa, Sven Trelle, Eveline Nüesch, Stephan Reichenbach
发表日期
2012/8/7
来源
Annals of internal medicine
卷号
157
期号
3
页码范围
180-191
出版商
American College of Physicians
简介
Background
Viscosupplementation, the intra-articular injection of hyaluronic acid, is widely used for symptomatic knee osteoarthritis.
Purpose
To assess the benefits and risks of viscosupplementation for adults with symptomatic knee osteoarthritis.
Data Sources
MEDLINE (1966 to January 2012), EMBASE (1980 to January 2012), the Cochrane Central Register of Controlled Trials (1970 to January 2012), and other sources.
Study Selection
Randomized trials in any language that compared viscosupplementation with sham or nonintervention control in adults with knee osteoarthritis.
Data Extraction
Primary outcomes were pain intensity and flare-ups. Secondary outcomes included function and serious adverse events. Reviewers used duplicate abstractions, assessed study …
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