作者
Darren R Mansfield, Peter Solin, Teanau Roebuck, Peter Bergin, David M Kaye, Matthew T Naughton
发表日期
2003/11/1
期刊
Chest
卷号
124
期号
5
页码范围
1675-1681
出版商
Elsevier
简介
Study objective
Central sleep apnea (CSA) associated with Cheyne-Stokes respiration in patients with congestive heart failure (CHF) is thought to be an acquired pattern of respiratory control instability related, at least in part, to elevated sympathetic nervous system activity. The effect of restoring heart function to normal with heart transplantation in patients with CHF and CSA has only been reported within weeks of the transplant and with varying results. The purpose of the study was to evaluate the impact of successful heart transplant on sympathetic nervous system activity and CSA severity in patients with CHF.
Design
Controlled prospective trial.
Setting
University hospital.
Patients
Twenty-two patients with CHF (13 patients with CSA, and 9 patients with no sleep-disordered breathing [SDB]).
Interventions and measurements
Polysomnography, left ventricular ejection fraction (LVEF), and overnight urinary …
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DR Mansfield, P Solin, T Roebuck, P Bergin, DM Kaye… - Chest, 2003