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The variables tested in multivariable analysis for predictors of in-hospital mortality were as follows: left ventricular ejection fraction, β-blocker before ES, diuretics, serum creatinine level, hemoglobin, pulmonary edema at the time of ES, and acute termination of ES after deep sedation. Among these variables, acute response to deep sedation was associated with a 55% lower risk of in-hospital death (subhazard ratio, 0.45 [95% CI, 0.22–0.93]; P= 0.03). Long-term survival did not differ between responders and nonresponders to deep sedation surviving to discharge. Current guidelines recommend deep sedation as a therapeutic option in ES refractory to antiarrhythmic drugs to reduce sympathetic overactivity involved in ES initiation and maintenance. 1 A rapid response to deep sedation≤ 15 minutes is critical to define a subgroup of patients at lower risk of in-hospital mortality. Conversely, alternative treatments should …