作者
Lisbeth Vandenput, Helena Johansson, EV McCloskey, Enwu Liu, KE Åkesson, FA Anderson, R Azagra, CL Bager, Charlotte Beaudart, HA Bischoff-Ferrari, E Biver, Olivier Bruyère, JA Cauley, JR Center, R Chapurlat, C Christiansen, Cyrus Cooper, Carolyn J Crandall, SR Cummings, JAP da Silva, Bess Dawson-Hughes, A Diez-Perez, Alyssa B Dufour, JA Eisman, Petra JM Elders, S Ferrari, Y Fujita, S Fujiwara, C-C Glüer, I Goldshtein, D Goltzman, V Gudnason, J Hall, Didier Hans, M Hoff, Rosemary J Hollick, Martijn Huisman, M Iki, S Ish-Shalom, G Jones, MK Karlsson, Sundeep Khosla, DP Kiel, W-P Koh, F Koromani, MA Kotowicz, H Kröger, T Kwok, Olivier Lamy, Arnulf Langhammer, Bagher Larijani, Kurt Lippuner, D Mellström, Thomas Merlijn, Annika Nordström, Peter Nordström, TW O’Neill, B Obermayer-Pietsch, C Ohlsson, ES Orwoll, JA Pasco, F Rivadeneira, B Schei, A-M Schott, EJ Shiroma, K Siggeirsdottir, EM Simonsick, E Sornay-Rendu, R Sund, KMA Swart, P Szulc, J Tamaki, DJ Torgerson, NM van Schoor, TP van Staa, J Vila, NJ Wareham, NC Wright, N Yoshimura, MC Zillikens, M Zwart, NC Harvey, M Lorentzon, WD Leslie, JA Kanis
发表日期
2022/10
来源
Osteoporosis international
卷号
33
期号
10
页码范围
2103-2136
出版商
Springer London
简介
We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.
Introduction
The availability of the fracture risk assessment tool FRAX® has substantially enhanced the targeting of treatment to those at high risk of fracture with FRAX now incorporated into more than 100 clinical osteoporosis guidelines worldwide. The aim of this study is to determine whether the current algorithms can be further optimised with respect to current and novel risk factors.
Methods
A computerised literature search was performed in PubMed from inception until May 17, 2019, to identify eligible cohorts for updating the FRAX coefficients. Additionally, we searched the …
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L Vandenput, H Johansson, EV McCloskey, E Liu… - Osteoporosis international, 2022
