作者
Geraldine Cambridge, Maria J Leandro, Jonathan CW Edwards, Michael R Ehrenstein, Martin Salden, Mark Bodman‐Smith, Anthony DB Webster
发表日期
2003/8
期刊
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
卷号
48
期号
8
页码范围
2146-2154
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To explore the changes in serologic variables and clinical disease activity following B lymphocyte depletion in 22 patients with rheumatoid arthritis (RA).
Methods
B lymphocyte depletion was attained using combination therapy based on the monoclonal anti‐CD20 antibody rituximab. Levels of a serologic indicator of inflammation, C‐reactive protein (CRP), of antimicrobial antibodies, of autoantibodies including IgA‐, IgM‐, and IgG‐class rheumatoid factors (RF), and of antibodies to cyclic citrullinated peptide (anti‐CCP) were assayed.
Results
The majority of patients showed a marked clinical improvement after treatment with rituximab, with benefit lasting up to 33 months. Levels of total serum immunoglobulins fell, although the mean values each remained within the normal range. Whereas the IgM‐RF response paralleled the changes in total serum IgM levels, the levels of IgA‐RF, IgG‐RF, and IgG and …
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