作者
Jingyi Yu, Marcus M Seldin, Kai Fu, Shen Li, Larry Lam, Ping Wang, Yijie Wang, Dian Huang, Thang L Nguyen, Bowen Wei, Rajan P Kulkarni, Dino Di Carlo, Michael Teitell, Matteo Pellegrini, Aldons J Lusis, Arjun Deb
发表日期
2018/6/22
期刊
Circulation research
卷号
123
期号
1
页码范围
73-85
出版商
Lippincott Williams & Wilkins
简介
Rationale:
Cardiac fibroblasts do not form a syncytium but reside in the interstitium between myocytes. This topological relationship between fibroblasts and myocytes is maintained throughout postnatal life until an acute myocardial injury occurs, when fibroblasts are recruited to, proliferate and aggregate in the region of myocyte necrosis. The accumulation or aggregation of fibroblasts in the area of injury thus represents a unique event in the life cycle of the fibroblast, but little is known about how changes in the topological arrangement of fibroblasts after cardiac injury affect fibroblast function.
Objective:
The objective of the study was to investigate how changes in topological states of cardiac fibroblasts (such as after cardiac injury) affect cellular phenotype.
Methods and Results:
Using 2 and 3-dimensional (2D versus 3D) culture conditions, we show that simple aggregation of cardiac fibroblasts is sufficient by itself to …
学术搜索中的文章
J Yu, MM Seldin, K Fu, S Li, L Lam, P Wang, Y Wang… - Circulation research, 2018