作者
Andrey Prilutskiy, Michael Kritselis, Artem Shevtsov, Ilyas Yambayev, Charitha Vadlamudi, Qing Zhao, Yachana Kataria, Shayna R Sarosiek, Adam Lerner, J Mark Sloan, Karen Quillen, Eric J Burks
发表日期
2020/10/1
期刊
American journal of clinical pathology
卷号
154
期号
4
页码范围
466-474
出版商
Oxford University Press
简介
Objectives
A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. However, clinicopathologic features diagnostic of hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the reticuloendothelial organs of 4 consecutive patients who died of COVID-19 and correlated with clinical and laboratory parameters to detect HLH.
Methods
Autopsies were performed on 4 patients who died of COVID-19. Routine H&E staining and immunohistochemical staining for CD163 were performed to detect hemophagocytosis. Clinical and laboratory results from premortem blood samples were used to calculate H-scores.
Results
All 4 cases demonstrated diffuse alveolar damage within the lungs. Three of the 4 cases had histologic evidence of hemophagocytosis within pulmonary lymph nodes. One case …
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