作者
Javid Sadri Nahand, Mohsen Moghoofei, Arash Salmaninejad, Zahra Bahmanpour, Mohammad Karimzadeh, Mitra Nasiri, Hamid Reza Mirzaei, Mohammad Hossein Pourhanifeh, Farah Bokharaei‐Salim, Hamed Mirzaei, Michael R Hamblin
发表日期
2020/1/15
来源
International journal of cancer
卷号
146
期号
2
页码范围
305-320
出版商
John Wiley & Sons, Inc.
简介
Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most important risk factor for the development of CC is cervical infection with human papilloma virus (HPV). Inflammation is a protective strategy that is triggered by the host against pathogens such as viral infections that acts rapidly to activate the innate immune response. Inflammation is beneficial if it is brief and well controlled; however, if the inflammation is excessive or it becomes of chronic duration, it can produce detrimental effects. HPV proteins are involved, both directly and indirectly, in the development of chronic inflammation, which is a causal factor in the development of CC. However, other factors may also have a potential role in stimulating chronic inflammation. MicroRNAs (miRNAs) (a class of noncoding RNAs) are strong regulators of gene expression. They have emerged as key players in several biological …
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