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Background and Aim: Studies have shown that breast cancer patients who have estrogen receptor (ER) or progesterone receptor (PR) positive tumors have lower risks of mortality and better response to treatment compared to women with ER and/or PR negative breast tumors. However, few studies have been performed about these factors and their relation with demographic or clinical characteristics in Iran. So we decided to evaluate the correlation between ER, PR and Human epidermal growth factor 2 (HER-2) with age, tumor size, tumor histological grade and lymph node metastasis as prognostic factors in breast cancer. Materials and Methods: In this cross sectional study, 138 patients with invasive ductal breast carcinoma who were admitted in Shohadaye Tajrish hospital during 2004-2005 were studied and all information was gathered from patients' medical records. Results: Statistically significant …