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The aim of this study was to determine the relationship between SOCIAL SUPPORT and SELF-ESTEEM, DEPRESSION and ANXIETY in patients with CANCER. Thisstudyis a correlation. Articipantsin the study included 200 patients who had CANCER in shahid Beheshti University of Medical Sciences, Shohada Hospital in Tehran. For Variable measuring DEPRESSION and ANXIETY scales, was used of the Beck DEPRESSION and ANXIETY and Cooper Smith's cast for variables of self-test and for SOCIAL SUPPORT variables SOCIAL SUPPORT Symnt was used. Data analysis and regression methods partial correlation coefficient was used. The results showed that relationship between SOCIAL SUPPORT and SELF-ESTEEM, DEPRESSION and ANXIETY in men and womenwith CANCER.