作者
Bertrand Guidet, Olivier Martinet, Thierry Boulain, Francois Philippart, Jean François Poussel, Julien Maizel, Xavier Forceville, Marc Feissel, Michel Hasselmann, Alexandra Heininger, Hugo Van Aken
发表日期
2012/6
期刊
Critical care
卷号
16
页码范围
1-10
出版商
BioMed Central
简介
Introduction
Inadequate initial treatment and delayed hemodynamic stabilization (HDS) may be associated with increased risk of death in severe sepsis patients.
Methods
In order to compare the hemodynamic efficacy and safety of 6% HES 130/0.4 and NaCl 0.9% for HDS in patients with severe sepsis, we designed a prospective, multicenter, active-controlled, double-blind, randomized study in intensive care units.
Results
174 out of 196 patients reached HDS (88 and 86 patients for HES and NaCl, respectively). Significantly less HES was used to reach HDS vs. NaCl (1,379 ±886 ml in the HES group and 1,709 ±1,164 ml in the NaCl group (mean difference = -331± 1,033, 95% CI -640 to -21, P = 0.0185). Time to reach HDS was 11.8 10.1 hours vs. 14.3 ±11.1 hours for HES and NaCl, respectively. Total quantity of study …
学术搜索中的文章
B Guidet, O Martinet, T Boulain, F Philippart… - Critical care, 2012