作者
Olivier Paccoud, Xavier Chamillard, Eric Kendjo, Isabelle Vinatier, Laure Surgers, Denis Magne, Benjamin Wyplosz, Adéla Angoulvant, Olivier Bouchaud, Arezki Izri, Sophie Matheron, Sandrine Houzé, Marc Thellier, Alioune P Ndour, Pierre Buffet, Eric Caumes, Stéphane Jauréguiberry, French National Reference Center for Imported Malaria Study Group
发表日期
2023/12/1
期刊
International Journal of Infectious Diseases
卷号
137
页码范围
144-148
出版商
Elsevier
简介
Objectives: Positive direct antiglobulin tests (DATs) have been reported in cases of post-artesunate delayed hemolysis (PADH), but the causal role of auto-immune hemolysis remains unclear. We aimed to analyze a cohort of patients with PADH and DAT during severe malaria.
Methods: We describe PADH and DAT results in a 7-year multi-center retrospective cohort of patients receiving artesunate for severe imported malaria.
Results: Of 337 patients treated with artesunate, 46 (13.6%) had at least one DAT result within 30 days of treatment initiation, and 25/46 (54.3%) had at least one positive DAT. Among 40 patients with available data, 17 (42.5%) experienced PADH. Patient characteristics were similar for patients with a positive or negative DAT, and DAT positivity was not associated with PADH occurrence (P = 0.36). Among patients, 5/13 (38.5%) with a positive DAT after day 7 experienced PADH, compared to 10 …
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O Paccoud, X Chamillard, E Kendjo, I Vinatier… - International Journal of Infectious Diseases, 2023