作者
Vincenzo Tumiatti, Andrea Milelli, Anna Minarini, Michela Rosini, Maria Laura Bolognesi, Marialuisa Micco, Vincenza Andrisano, Manuela Bartolini, Francesca Mancini, Maurizio Recanatini, Andrea Cavalli, Carlo Melchiorre
发表日期
2008/11/27
期刊
Journal of medicinal chemistry
卷号
51
期号
22
页码范围
7308-7312
出版商
American Chemical Society
简介
Novel multi-target-directed ligands were designed by replacing the inner dipiperidino function of 3 with less flexible or completely rigid moieties to obtain compounds endowed with multiple biological properties that might be relevant to Alzheimer’s disease. 15 was the most interesting, inhibiting AChE in the nanomolar range and inhibiting AChE-induced and self-promoted β-amyloid aggregation in the micromolar range.
学术搜索中的文章
V Tumiatti, A Milelli, A Minarini, M Rosini, ML Bolognesi… - Journal of medicinal chemistry, 2008