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The search for drugs to save, preserve, and enhance our lives has long posed great challenges to human effort. Since early times, thanks to the pioneering work of alchemists and then medicinal chemists, humanity has benefited enormously from drug discovery. Nowadays, sophisticated procedures for drug synthesis and target elucidation allow us to design molecules with relative ease and with the hope that these new molecules will become effective medicinal drugs. However, drug designers still face great challenges mainly because there is no agreement on how to do the job correctly. A key issue in drug discovery is the selection of a lead molecule suitable for developing new molecules for treating diseases. 1 Crucially, how many potential drug targets are responsible for the pathogenic factors leading to a given disease? 2 In general, 20th century drug research aimed to discover drugs that could hit a single …