作者
Lorenzo Galluzzi, Bravo-San Pedro, IGOR Vitale, SA Aaronson, JM Abrams, D Adam, ES Alnemri, Lucia Altucci, D Andrews, M Annicchiarico-Petruzzelli, EH Baehrecke, NG Bazan, MJ Bertrand, Katiuscia Bianchi, MV Blagosklonny, K Blomgren, C Borner, DE Bredesen, C Brenner, M Campanella, E Candi, F Cecconi, FK Chan, NAVDEEP SINGH Chandel, EH Cheng, JE Chipuk, JA Cidlowski, A Ciechanover, TM Dawson, VL Dawson, Vincenzo De Laurenzi, R De Maria, KM Debatin, N Di Daniele, VM Dixit, BD Dynlacht, WS El-Deiry, Gian Maria Fimia, RA Flavell, S Fulda, C Garrido, ML Gougeon, DR Green, H Gronemeyer, Gyorgy Hajnoczky, JM Hardwick, MO Hengartner, H Ichijo, B Joseph, PJ Jost, T Kaufmann, O Kepp, DJ Klionsky, RA Knight, S Kumar, JJ Lemasters, B Levine, A Linkermann, SA Lipton, RA Lockshin, C López-Otín, E Lugli, F Madeo, W Malorni, JC Marine, SJ Martin, JC Martinou, Jan Paul Medema, P Meier, Sm Melino, N Mizushima, U Moll, C Muñoz-Pinedo, G Nuñez, A Oberst, T Panaretakis, JM Penninger, ME Peter, M Piacentini, Paolo Pinton, JH Prehn, H Puthalakath, GA Rabinovich, KS Ravichandran, Rosario Rizzuto, CM Rodrigues, DC Rubinsztein, T Rudel, Y Shi, HU Simon, BR Stockwell, Gyorgy Szabadkai, SW Tait, HL Tang, N Tavernarakis, Y Tsujimoto, Tom Vanden Berghe, Peter Vandenabeele, A Villunger, EF Wagner, H Walczak, E White, WG Wood, J Yuan, Z Zakeri, Boris Zhivotovsky, G Melino, G Kroemer
发表日期
2015/1
来源
Cell Death & Differentiation
卷号
22
期号
1
页码范围
58-73
出版商
Nature Publishing Group
简介
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’(ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions.‘Regulated cell death’(RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of …
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L Galluzzi, BS Pedro, I Vitale, SA Aaronson, JM Abrams… - Cell Death & Differentiation, 2015
