作者
A Tommasini, TARCISIO Not, V Kiren, V Baldas, D Santon, C Trevisiol, I Berti, E Neri, T Gerarduzzi, I Bruno, A Lenhardt, E Zamuner, A Spano, Sergio Crovella, S Martellossi, G Torre, Daniele Sblattero, ROBERTO Marzari, A Bradbury, G Tamburlini, Alessandro Ventura
发表日期
2004/6/1
期刊
Archives of disease in childhood
卷号
89
期号
6
页码范围
512-515
出版商
BMJ Publishing Group Ltd
简介
Aims: To determine coeliac disease prevalence by an anti-transglutaminase antibody assay in a large paediatric population; to evaluate acceptance of the screening programme, dietary compliance, and long term health effects.
Methods: Cross-sectional survey of 3188 schoolchildren (aged 6–12) and prospective follow up of diagnosed cases. Main outcome measures were: prevalence of coeliac disease defined by intestinal biopsy or positivity to both human tissue transglutaminase and anti-endomysium antibodies in HLA DQ2-8 positive subjects; percentage of children whose families accepted screening; dietary compliance as defined by negativity for anti-transglutaminase antibodies; and presence of clinical or laboratory abnormalities at 24 month follow up.
Results: The families of 3188/3665 children gave their consent (87%). Thirty biopsy proven coeliacs were identified (prevalence 1:106). Three other …
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