作者
Julio Licinio, Christos Mantzoros, Anadré B Negrão, Giovanni Cizza, Ma-Li Wong, Peter B Bongiorno, George P Chrousos, Brian Karp, Christine Allen, Jeffrey S Flier, Philip W Gold
发表日期
1997/5/1
期刊
Nature medicine
卷号
3
期号
5
页码范围
575-579
出版商
Nature Publishing Group US
简介
Leptin communicates nutritional status to regulatory centers in the brain1,2. Because peripheral leptin influences the activity of the highly pulsatile adrenal and gonadal axes3,4, we sought to determine whether leptin levels in the blood are pulsatile. We measured circulating leptin levels every 7 minutes for 24 hours, in six healthy men, and found that total circulating leptin levels exhibited a pattern indicative of pulsatile release, with 32.0 ± 1.5 pulses every 24 hours and a pulse duration of 32.8 ± 1.6 minutes. We also show an inverse relation between rapid fluctuations in plasma levels of leptin and those of adrenocorticotropic hormone (ACTH) and cortisol that could not be accounted for on the basis of glucocorticoid suppression of leptin. As leptin levels are pulsatile, we propose that a key function of the CNS is regulated by a peripheral pulsatile signal. In a separate pilot study we compared leptin pulsatility in 414 …
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J Licinio, C Mantzoros, AB Negrão, G Cizza, ML Wong… - Nature medicine, 1997