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Long COVID is a wide range of new, returning, or ongoing health problems experienced after primary COVID-19 infection, with a possibility of broad adverse outcomes. The aim of this study was to determine the case fatality of of post-acute sequelae of COVID-19 (PASC) and assess possible covariates. We conducted a systematic review and meta-analysis from 43 studies (367,236 patients),(June, 2020-August, 2022). PASC mortality was assessed from six studies. With random-effects model, the pooled case fatality was measured. Publication bias was ascertained and meta-regression analysis done on predetermined covariates. The estimated prevalence of PASC was 42.5%(95% CI= 36.0%-49.3%). The pooled case fatality was 7.4%(95% CI= 7.4% to 11.2%). The funnel plot suggested the presence of publication bias. Hospital re-admission (P= 0.0034)(R²= 1.00) and the year 2021 (P= 0.0309)(R²= 0.55) were associated with fatalities from PASC. PASC increased the case-fatality of COVID-19, particularly during the year 2021, reflecting a longer follow-up of patients and with hospital re-admission. It is recommended to monitor patients re-admitted to hospital post index COVID-19 closely monitor specific clinical parameters that may increase the risk of death.