作者
Gabriela C Sena, Leandro C Freitas-Lima, Eduardo Merlo, Priscila L Podratz, Julia FP de Araújo, Poliane AA Brandão, Maria TWD Carneiro, Marina C Zicker, Adaliene VM Ferreira, Christina M Takiya, Carolina M de Lemos Barbosa, Marcelo M Morales, Ana Paula Santos-Silva, Leandro Miranda-Alves, Ian V Silva, Jones B Graceli
发表日期
2017/3/15
期刊
Toxicology and Applied Pharmacology
卷号
319
页码范围
22-38
出版商
Academic Press
简介
Tributyltin chloride (TBT) is a xenobiotic used as a biocide in antifouling paints that has been demonstrated to induce endocrine-disrupting effects, such as obesity and reproductive abnormalities. An integrative metabolic control in the hypothalamus-pituitary-gonadal (HPG) axis was exerted by leptin. However, studies that have investigated the obesogenic TBT effects on the HPG axis are especially rare. We investigated whether metabolic disorders as a result of TBT are correlated with abnormal hypothalamus-pituitary-gonadal (HPG) axis function, as well as kisspeptin (Kiss) action. Female Wistar rats were administered vehicle and TBT (100 ng/kg/day) for 15 days via gavage. We analyzed their effects on the tin serum and ovary accumulation (as biomarker of TBT exposure), estrous cyclicity, surge LH levels, GnRH expression, Kiss action, fertility, testosterone levels, ovarian apoptosis, uterine inflammation, fibrosis …
学术搜索中的文章
GC Sena, LC Freitas-Lima, E Merlo, PL Podratz… - Toxicology and Applied Pharmacology, 2017