作者
Yoosoo Chang, Hyun-Suk Jung, Juhee Cho, Yiyi Zhang, Kyung Eun Yun, Mariana Lazo, Roberto Pastor-Barriuso, Jiin Ahn, Chan-Won Kim, Sanjay Rampal, Miguel Cainzos-Achirica, Di Zhao, Eun Cheol Chung, Hocheol Shin, Eliseo Guallar, Seungho Ryu
发表日期
2016/8/1
期刊
Official journal of the American College of Gastroenterology| ACG
卷号
111
期号
8
页码范围
1133-1140
出版商
LWW
简介
OBJECTIVES:
The risk of nonalcoholic fatty liver disease (NAFLD) among obese individuals without obesity-related metabolic abnormalities, a condition referred to as metabolically healthy obese (MHO), is largely unexplored. Therefore, we examined the association between body mass index (BMI) categories and the development of NAFLD in a large cohort of metabolically healthy men and women.
METHODS:
A cohort study was conducted in 77,425 men and women free of NAFLD and metabolic abnormalities at baseline, who were followed-up annually or biennially for an average of 4.5 years. Being metabolically healthy was defined as not having any metabolic syndrome component and having a homeostasis model assessment of insulin resistance< 2.5. The presence of fatty liver was determined using ultrasound.
RESULTS:
During 348,193.5 person-years of follow-up, 10,340 participants developed NAFLD …
学术搜索中的文章
Y Chang, HS Jung, J Cho, Y Zhang, KE Yun, M Lazo… - Official journal of the American College of …, 2016