作者
Lars Egevad, Daniela Swanberg, Brett Delahunt, Peter Ström, Kimmo Kartasalo, Henrik Olsson, Dan M Berney, David G Bostwick, Andrew J Evans, Peter A Humphrey, Kenneth A Iczkowski, James G Kench, Glen Kristiansen, Katia RM Leite, Jesse K McKenney, Jon Oxley, Chin-Chen Pan, Hemamali Samaratunga, John R Srigley, Hiroyuki Takahashi, Toyonori Tsuzuki, Theo van der Kwast, Murali Varma, Ming Zhou, Mark Clements, Martin Eklund
发表日期
2020/12
期刊
Virchows Archiv
卷号
477
页码范围
777-786
出版商
Springer Berlin Heidelberg
简介
The International Society of Urological Pathology (ISUP) hosts a reference image database supervised by experts with the purpose of establishing an international standard in prostate cancer grading. Here, we aimed to identify areas of grading difficulties and compare the results with those obtained from an artificial intelligence system trained in grading. In a series of 87 needle biopsies of cancers selected to include problematic cases, experts failed to reach a 2/3 consensus in 41.4% (36/87). Among consensus and non-consensus cases, the weighted kappa was 0.77 (range 0.68–0.84) and 0.50 (range 0.40–0.57), respectively. Among the non-consensus cases, four main causes of disagreement were identified: the distinction between Gleason score 3 + 3 with tangential cutting artifacts vs. Gleason score 3 + 4 with poorly formed or fused glands (13 cases), Gleason score 3 + 4 vs. 4 + 3 (7 cases), Gleason …
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L Egevad, D Swanberg, B Delahunt, P Ström… - Virchows Archiv, 2020