作者
Sanjay Gupta, Tajamul Hussain, Gregory T MacLennan, Pingfu Fu, Jigar Patel, Hasan Mukhtar
发表日期
2003/1/1
期刊
Journal of Clinical Oncology
卷号
21
期号
1
页码范围
106-112
出版商
American Society of Clinical Oncology
简介
Purpose: To establish the clinical significance of calcium binding proteins S100A2 and S100A4 during progression of human prostate adenocarcinoma.
Patients and Methods: Expression pattern of S100A2 and S100A4 was determined in normal human prostate epithelial cells (NHPE); virally transformed prostate epithelial cells (PZ-HPV-7); several human prostate carcinoma cells (22Rv1, DU145, LNCaP, and PC3); tissue samples obtained during transuretheral prostatic resection from patients with benign prostate hyperplasia (BPH), prostatitis, and adenocarcinoma; and paraffin-embedded sections from pair-matched benign and cancer specimens of different tumor grade.
Results: High constitutive protein expression of S100A2 was observed in NHPE and PZ-HPV-7 cells, whereas its complete absence was observed in 22Rv1, DU145, LNCaP, and PC3 cells. Tissue samples of BPH and prostatitis exhibited …
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S Gupta, T Hussain, GT MacLennan, P Fu, J Patel… - Journal of Clinical Oncology, 2003